Angioinvasive aspergillosis mimicking giant cell arteritis in an 81-year-old man with jaw pain and vision loss

Angioinvasive aspergillosis mimicking giant cell arteritis in an 81-year-old man with jaw pain and vision loss

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The present case report focuses on an immunocompromised 81-year-old patient initially diagnosed with Waldenström’s disease.The patient experienced a gradual vision loss and jaw pain with high erythrocyte sedimentation rate.We first suspected giant cell arteritis, despite inconclusive assessment, including a negative temporal artery biopsy.

We rapidly started a corticosteroid pulse therapy followed by high-dose corticosteroid therapy nacrack.com that was followed even after discharge from the hospital.The patient was readmitted 20 days later with severe left retro-orbital pain and progressive left vision loss.Clinical examination revealed complete left eyelid ptosis and unilateral blindness with fixed mydriasis and iphone 13 pro max price winnipeg no eye movement.

MRI showed signs of ischaemic optic neuropathy with lysis of the left ethmoid sinus wall; thus, indicating ischaemic optic neuropathy related to lymphoplasmacytic infiltration of Waldenström’s disease (Bing-Neel syndrome).Oncological treatment of ibrutinib, a tyrosine kinase inhibitor, was then administered.Despite a favourable prognosis, no improvement was seen.

An infectious aetiology was finally confirmed.The left sphenoid sinus biopsy highlighted an angioinvasive aspergillosis with rhino-orbital infiltration observed as ischaemic optic neuropathy.Oncologic treatment was discontinued and antifungal therapy with voriconazole was introduced, leading to a favourable radiological development and analgesic control, without ophtalmological improvement.